Irinotecan (Campto®) – Colorectal cancer 2nd line

NICE recommendations, summary of meeting discussions, links to additional supporting docs etc.

NICE TA 93 (August 2005):

Irinotecan and oxaliplatin are recommended as possible treatments for people with advanced colorectal cancer, if they are used in these ways:

Irinotecan is given with 5-fluorouracil and folinic acid to people who have not had chemotherapy for advanced colorectal cancer before, or given on its own to people who have already had chemotherapy.

Oxaliplatin is always given with 5-fluorouracil and folinic acid.

Raltitrexed is not recommended for people with advanced colorectal cancer, unless they are taking part in a clinical trial.

April 2013: NHS England SCG took over commissioning responsibility for this treatment.

January 2015:  The TAG noted NICE CG 131for the diagnosis and management of colorectal cancer but did not make any specific “traffic light” recommendations for this SCG commissioned treatment.

January 2015:  The Norfolk & Waveney CCGs’ D&TCG noted the NICE CG 131.